| 2022-06-29 20:00:36Jun 29, 2022 | FC Mayaguez vs Puerto Rico Sol | 0 - 3 | Estadio Centroamericano |
| 2022-06-29 20:00:35Jun 29, 2022 | Caguas Sporting FC vs CF Fraigcomar | 0 - 11 | Estadio Benjamín "Pito Cornflakes" Martínez |
| 2022-06-26 19:00:16Jun 26, 2022 | Caguas Sporting FC vs Puerto Rico Sol | 3 - 1 | Estadio Centroamericano |
| 2022-06-26 15:00:02Jun 26, 2022 | Bayamón FC vs Metropolitan Football Academy | 1 - 2 | Estadio Juan Ramón Loubriel |
| 2022-06-25 18:00:59Jun 25, 2022 | Academia Quintana vs Guaynabo GOL | 3 - 2 | Estadio Benjamín "Pito Cornflakes" Martínez |
| 2022-06-22 20:00:42Jun 22, 2022 | FC Mayaguez vs Bayamón FC | 0 - 3 | Estadio Centroamericano |
| 2022-06-22 20:00:32Jun 22, 2022 | Guaynabo GOL vs Metropolitan Football Academy | 0 - 6 | Estadio Reparto Metropolitano |
| 2022-06-19 19:00:22Jun 19, 2022 | Puerto Rico Sol vs Bayamón FC | 3 - 1 | Estadio Juan Ramón Loubriel |
| 2022-06-19 18:00:43Jun 19, 2022 | FC Mayaguez vs CF Fraigcomar | 0 - 3 | Estadio Centroamericano |
| 2022-06-18 20:00:03Jun 18, 2022 | Metropolitan Football Academy vs Academia Quintana | 4 - 1 | Estadio Benjamín "Pito Cornflakes" Martínez |
| 2022-06-18 17:45:30Jun 18, 2022 | Guaynabo GOL vs Caguas Sporting FC | 4 - 0 | Estadio Benjamín "Pito Cornflakes" Martínez |
| 2022-06-15 20:30:47Jun 15, 2022 | CF Fraigcomar vs FC Mayaguez | 7 - 0 | Estadio Benjamín "Pito Cornflakes" Martínez |
| 2022-06-15 20:00:24Jun 15, 2022 | Bayamón FC vs Academia Quintana | 2 - 1 | Estadio Juan Ramón Loubriel |
| 2022-06-11 18:00:22Jun 11, 2022 | Academia Quintana vs CF Fraigcomar | 1 - 2 | Estadio Benjamín "Pito Cornflakes" Martínez |
| 2022-06-09 20:00:22Jun 9, 2022 | Caguas Sporting FC vs Metropolitan Football Academy | 1 - 9 | Estadio Benjamín "Pito Cornflakes" Martínez |
| 2022-06-05 20:00:58Jun 5, 2022 | Academia Quintana vs Caguas Sporting FC | 7 - 1 | Estadio Benjamín "Pito Cornflakes" Martínez |
| 2022-06-05 18:30:34Jun 5, 2022 | CF Fraigcomar vs Bayamón FC | 0 - 6 | Estadio Juan Ramón Loubriel |
| 2022-06-04 20:30:54Jun 4, 2022 | Metropolitan Football Academy vs FC Mayaguez | 9 - 0 | Estadio Benjamín "Pito Cornflakes" Martínez |
| 2022-06-04 18:00:09Jun 4, 2022 | Guaynabo GOL vs Puerto Rico Sol | 1 - 2 | Estadio Benjamín "Pito Cornflakes" Martínez |
| 2022-06-02 20:00:57Jun 2, 2022 | Bayamón FC vs Guaynabo GOL | 4 - 0 | Estadio Juan Ramón Loubriel |
| 2022-06-02 20:00:12Jun 2, 2022 | Caguas Sporting FC vs CF Fraigcomar | 3 - 6 | Estadio Benjamín "Pito Cornflakes" Martínez |
| 2022-06-01 20:00:47Jun 1, 2022 | FC Mayaguez vs Puerto Rico Sol | 0 - 3 | Estadio Centroamericano |
| 2022-05-29 20:00:39May 29, 2022 | Bayamón FC vs Caguas Sporting FC | 4 - 0 | Estadio Benjamín "Pito Cornflakes" Martínez |
| 2022-05-29 17:00:27May 29, 2022 | FC Mayaguez vs Academia Quintana | 0 - 11 | Estadio Benjamín "Pito Cornflakes" Martínez |
| 2022-05-28 20:30:26May 28, 2022 | CF Fraigcomar vs Guaynabo GOL | 0 - 2 | Estadio Benjamín "Pito Cornflakes" Martínez |
| 2022-05-27 20:30:17May 27, 2022 | Puerto Rico Sol vs Metropolitan Football Academy | 0 - 2 | Estadio Benjamín "Pito Cornflakes" Martínez |
| 2022-05-22 20:00:32May 22, 2022 | Academia Quintana vs Puerto Rico Sol | 1 - 2 | Estadio Centroamericano |
| 2022-05-22 18:30:05May 22, 2022 | CF Fraigcomar vs Metropolitan Football Academy | 2 - 6 | Estadio Juan Ramón Loubriel |
| 2022-05-22 17:00:59May 22, 2022 | FC Mayaguez vs Caguas Sporting FC | 1 - 4 | Estadio Centroamericano |
| 2022-05-18 20:00:56May 18, 2022 | FC Mayaguez vs Bayamón FC | 0 - 10 | Estadio Centroamericano |
| 2022-05-15 19:45:34May 15, 2022 | Puerto Rico Sol vs CF Fraigcomar | 1 - 1 | Estadio Benjamín "Pito Cornflakes" Martínez |
| 2022-05-14 19:45:26May 14, 2022 | FC Mayaguez vs Guaynabo GOL | 0 - 3 | Estadio Benjamín "Pito Cornflakes" Martínez |
| 2022-05-13 19:45:07May 13, 2022 | Academia Quintana vs CF Fraigcomar | 2 - 1 | Estadio Benjamín "Pito Cornflakes" Martínez |
| 2022-05-08 16:30:08May 8, 2022 | Metropolitan Football Academy vs Academia Quintana | 3 - 2 | Estadio Centroamericano |
| 2022-05-06 20:00:21May 6, 2022 | Puerto Rico Sol vs Bayamón FC | 1 - 1 | Estadio Benjamín "Pito Cornflakes" Martínez |
| 2022-05-01 20:00:38May 1, 2022 | Bayamón FC vs Metropolitan Football Academy | 2 - 2 | Estadio Benjamín "Pito Cornflakes" Martínez |
| 2022-05-01 17:00:32May 1, 2022 | Academia Quintana vs Guaynabo GOL | 3 - 1 | Estadio Benjamín "Pito Cornflakes" Martínez |
| 2022-04-29 20:15:10Abr 29, 2022 | Guaynabo GOL vs Metropolitan Football Academy | 0 - 4 | Estadio Benjamín "Pito Cornflakes" Martínez |
| 2022-04-23 20:15:46Abr 23, 2022 | Guaynabo GOL vs Caguas Sporting FC | 2 - 0 | Estadio Benjamín "Pito Cornflakes" Martínez |
| 2022-04-10 19:15:29Abr 10, 2022 | Caguas Sporting FC vs Puerto Rico Sol | 1 - 4 | Estadio Benjamín "Pito Cornflakes" Martínez |
| 2022-04-03 19:45:24Abr 3, 2022 | Academia Quintana vs Caguas Sporting FC | 3 - 0 | Estadio Benjamín "Pito Cornflakes" Martínez |
| 2022-04-03 19:15:18Abr 3, 2022 | Guaynabo GOL vs Puerto Rico Sol | 2 - 3 | Estadio Centroamericano |
| 2022-04-03 16:15:35Abr 3, 2022 | Metropolitan Football Academy vs FC Mayaguez | 2 - 0 | Estadio Centroamericano |
| 2022-04-02 20:15:21Abr 2, 2022 | CF Fraigcomar vs Bayamón FC | 1 - 5 | Estadio Benjamín "Pito Cornflakes" Martínez |
| 2022-03-27 19:15:28Mar 27, 2022 | Bayamón FC vs Caguas Sporting FC | 8 - 0 | Estadio Benjamín "Pito Cornflakes" Martínez |
| 2022-03-27 16:45:05Mar 27, 2022 | Puerto Rico Sol vs Metropolitan Football Academy | 1 - 1 | Estadio Benjamín "Pito Cornflakes" Martínez |
| 2022-03-27 14:45:08Mar 27, 2022 | CF Fraigcomar vs Guaynabo GOL | 2 - 1 | Albergue Olímpico |
| 2022-03-26 17:45:14Mar 26, 2022 | FC Mayaguez vs Academia Quintana | 1 - 4 | Estadio Benjamín "Pito Cornflakes" Martínez |
| 2022-03-20 19:45:48Mar 20, 2022 | Academia Quintana vs Puerto Rico Sol | 3 - 0 | Estadio Benjamín "Pito Cornflakes" Martínez |
| 2022-03-20 16:45:07Mar 20, 2022 | Metropolitan Football Academy vs CF Fraigcomar | 0 - 5 | Estadio Benjamín "Pito Cornflakes" Martínez |
| 2022-03-20 14:45:52Mar 20, 2022 | Caguas Sporting FC vs FC Mayaguez | 0 - 0 | Albergue Olímpico |
| 2022-03-19 20:15:03Mar 19, 2022 | Bayamón FC vs Guaynabo GOL | 2 - 0 | Estadio Benjamín "Pito Cornflakes" Martínez |
| 2022-03-13 19:15:30Mar 13, 2022 | Caguas Sporting FC vs Metropolitan Football Academy | 1 - 1 | Estadio Benjamín "Pito Cornflakes" Martínez |
| 2022-03-13 19:15:08Mar 13, 2022 | FC Mayaguez vs Guaynabo GOL | 1 - 4 | Estadio Centroamericano |
| 2022-03-13 16:15:38Mar 13, 2022 | Puerto Rico Sol vs CF Fraigcomar | 1 - 1 | Estadio Centroamericano |
| 2022-03-12 20:45:01Mar 12, 2022 | Bayamón FC vs Academia Quintana | 0 - 1 | Estadio Benjamín "Pito Cornflakes" Martínez |
